Drekonja DM, Trautner B, Amundson C, et al. - Researchers conducted a randomized clinical trial including 272 men with presumed symptomatic urinary tract infection (UTI) with the aim to determine if treatment with ciprofloxacin or trimethoprim/sulfamethoxazole for 7 days is noninferior to 14 days of treatment with regard to resolution of UTI symptoms. In the 7-day group and the 14-day group, 122 of 131 (93.1%) participants and 111 of 123 (90.2%) participants, respectively, had resolution of initial UTI symptoms by 14 days after completion of active antibiotic therapy, a difference that met the prespecified noninferiority margin of 10%. These findings yield support for using a 7-day course of ciprofloxacin or trimethoprim/sulfamethoxazole as an alternative to a 14-day course for managing afebrile men with suspected UTI.