Shah S, et al. - A case of a 35-year-old woman with refractory lupus nephritis who developed asymptomatic early onset neutropenia and thrombocytopenia following rituximab infusion was described in this work. A good response of neutropenia to granulocyte colony-stimulating factor treatment and spontaneous recovery of platelets were observed. As per this case report, identification of early-onset cytopenia following rituximab is significant as it may have an important bearing on the final outcome in patient.