Hammond NG, et al. - Researchers investigated the association of early life stressors with adolescent headache in a Canadian cohort, and determined the potential mediating influence of symptoms of depression and anxiety on this association. Data were collected and analyzed from 2,313 respondents of the National Longitudinal Survey of Children and Youth. Prospective follow-up was performed from age 0 to 1 year at baseline (1994/1995) until age 14 to 15 years (2008/2009). Incident migraine and frequent headache was evident in 3.1% and 11.1%, respectively, among respondents. According to findings, early life family-level factors may influence the prospective risk of developing a migraine, through symptoms of depression and anxiety. In addition, unnecessary stress-related burdens on children and adolescents may decrease upon addressing family dynamics in clinical practice, which may, in turn, lead to improvements in somatic complaints.