Thomas PE, et al. - A large Danish observational cohort study was designed to evaluate whether birthweight, childhood body mass index (BMI; [kg/m2]), height and growth are associated with risks of adult systemic lupus erythematosus (SLE). A sum of 346,627 children from the Copenhagen School Health Records Register, born 1930-1996 with measured weights and heights from 7-13 years were included in this study. They carried out Cox proportional hazards regressions to measure hazard ratios (HR) and 95% confidence intervals (CI). There were differences by gender in any of the associations. Birthweight was not correlated with SLE risks. The study found that childhood body size is correlated with risks of adult SLE, which confirms the hypothesis that early life factors are important in SLE aetiology.