Faure‐Bardon V J. Fourgeaud T. Guilleminot, et al. - Researchers aimed at evaluating the feasibility of amplification of the viral genome by PCR on chorionic villi retrieved by Chorion Villus Sampling (CVS) in cases of Maternal Primary Infection (MPI) with CMV in early pregnancy. CMV serology screening was performed in early pregnancy, the women were offered CVS at 11‐14 weeks’ after CMV MPI before 10 weeks’ following consent for array‐CGH and amplification of the viral genome by PCR on the trophoblast obtained by CVS. In addition, amniocentesis was performed in all cases from 17 weeks’ onwards for PCR in amniotic fluid. At 12.7 (11.3‐14.4) weeks’, 37 CVS were performed. Three cases had positive and 34 cases had negative CMV PCR. PCR amplification of the CMV genome in chorionic villi can aid in achieving diagnosis of placental infection following MPI in early pregnancy. Long‐term follow‐up evaluation is required to assess if negative CMV PCR in trophoblast after 12 weeks’ could exclude the risk of CMV‐related embryopathy leading to sequelae. This could establish CVS as the diagnostic test after maternal serology screening in early pregnancy.