• Profile
Close

Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma

Journal of Ovarian Research Aug 11, 2017

Jiang RT, et al. – Here, researchers sought to find out whether RPN13 is available as a target in precursors of ovarian/fallopian tube cancer and also all advanced cases and the effect of increased ADRM1 gene copy number on the sensitivity of ovarian cancer to RA190. RPN13 can potentially be targeted by RA190 in both in situ and metastatic ovarian carcinoma. Ovarian cancer cell lines are sensitive to RA190 regardless of whether the ADRM1 gene is amplified.

Methods

  • ADRM1 mRNA was measured by RNAscope in situ hybridization and RPN13 protein detected by immunohistochemistry in high–grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC).
  • Amplification of ADRM1 and sensitivity to RA190 were determined in ovarian cancer cell lines.

Results

  • Here, they show that expression of ADRM1mRNA is significantly elevated in STIC and HGSC as compared to normal fallopian tube epithelium.
  • ADRM1 mRNA and RPN13 were ubiquitously and robustly expressed in ovarian carcinoma tissue and cell lines.
  • No correlation was observed between ADRM1 amplification and sensitivity of ovarian cancer cell lines to RA190, but all were susceptible.

Full text available Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay