Gita JB, et al. - Researchers conducted this case-control study to examine the function of inflammatory microRNA, miR-146a, in acute coronary syndrome (ACS) patients with and without chronic periodontitis (CP) and its regulation of the innate immune host response to periodontal pathogens. The study population was created by three groups of 66 patients each, with group 1 including ACS patients without CP, group 2 including ACS patients with CP, and group 3 including patients with CP only. Findings suggested that miR-146a can be considered a crucial molecule that modulates the immunoinflammatory response in patients with periodontitis, thereby increasing the risk of ACS.