Gregory JM, Livesey MR, McDade K, et al. - Researchers gave the first relative quantitative evaluation of the expression profile of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPAR) subunit transcripts, using BaseScope, in postmortem lower motor neurons (spinal cord, anterior horn), upper motor neurons (motor cortex) and neurons of the prefrontal cortex in sporadic forms of amyotrophic lateral sclerosis (ALS) and familial causes of ALS because of mutations in SOD1 and C9orf72. Data reflects the complex dysregulation of AMPAR subunit expression that reveals both converging and diverging mechanisms at play among various brain regions and between ALS cohorts.