Echouffo-Tcheugui JB, Mwasongwe SE, Musani SK, et al. - A higher risk of heart failure (HF) subtypes was observed in relation to higher levels of glycemic markers in community-dwelling Blacks.

• Participants were selected from the Jackson Heart Study, and included 2,290 community-dwelling Blacks (64% women, mean age 58 years) without prevalent HF who attended the second exam (2005-2008).

• A higher risk of incident HF was observed in relation to higher levels of hemoglobin A _1C (HbA _1C ) (HR per SD increase, 1.30; 95% CI 1.12, 1.51) and fasting plasma glucose (FPG) (HR per SD increment FPG: 1.32; 95% CI: 1.17, 1.48).

• Diabetes status, vs normal glycemia, was linked with a higher risk of incident HF (HR: 1.24).

• Significant association of HbA _1C with higher risks of HF with preserved ejection fraction [HFpEF] (HR per SD increase: 1.41, 95% CI: 1.18, 1.69) and HF with reduced ejection fraction [HFrEF] (HR per SD increase: 1.32; 95% CI: 1.12, 1.56) was identified.

• FPG was found to be significantly related to higher risk of HFpEF (HR per SD increase: 1.35, 95% CI: 1.14, 1.62) but not HFrEF (HR per SD increase: 1.12; 95% CI: 0.53, 2.35).