Rasmussen SR, Kandler K, Nielsen RV, et al. - In order to examine the influence of the duration of low oxygen delivery (< 272 mL. min⁻¹.m⁻²), during cardiopulmonary bypass on kidney function, individuals (n = 1,968) who were undergoing coronary artery bypass graft surgery ± valve repair were involved by the researchers. Postoperative peak serum creatinine, the incidence of acute kidney injury, and demand for dialysis rose in a dose-dependent manner in association with the duration of a mean oxygen delivery < 272 mL. min⁻¹.m⁻². Using multiple regression analyses only exposure for at least 30 minutes was independently correlated with elevated peak serum creatinine and acute kidney injury. On the contrary, both short and at least 30 min exposure to low DO₂ were both independently related to the requirement for renal replacement therapy. Thus, during cardiopulmonary bypass, a low oxygen delivery was in a dose-dependent manner correlated with an elevated risk of renal injury.