Ling S, Sun P, Zaccardi F, et al. - Using data from the DISCOVER observational study, researchers developed and internally validated prognostic models on the long-term durability of glycaemic control in individuals with T2D after metformin failure. In this analysis from 35 countries, due to a physician-defined lack of efficacy, patients on metformin starting second-line glucose-lowering medication(s) were included. Of the 2,995 people involved in the current analysis, 896 achieved sustained glycaemic control. They built and validated two models for predicting the durability of glycaemic control in people with T2D at the start of second-line glucose-lowering therapies after metformin failure; the individual chance of sustained glycaemic control within 2 years can be estimated utilizing simple information that is routinely collected in primary care. While further research is needed to externally validate the models, they have incorporated them into a web application that dynamically estimates the chance of achieving sustained glycaemic control over 2 years, based on the characteristics of an individual patient. This tool could be used as an easily accessible resource for practitioners to help improve the management of glucose-lowering patients following metformin failure.