Pitre T, et al. - Given the implication of both prescription and natural health products (NHPs) in drug-induced liver injury (DILI), an important cause of acute liver injury that accounts for nearly 10% of all cases of acute hepatitis, researchers here report on a previously healthy 37-year-old female presenting with subacute hepatitis, in the context of a previous admission to a separate institution, months prior for undiagnosed acute hepatitis. She had predominant pathological features of drug-induced liver injury; although the core liver biopsies showed an abnormal amount of copper. However, normal serum ceruloplasmin and 24-urine copper ruled out Wilson’s disease. Stopping all the NHPs led to significant improvement in this patient, although evidence of fibrosis was noted on ultrasound at last available follow-up. Relative to the ingestion of individual products alone, the combination of various naturopathic medications may result in more sustained liver injury and hepatotoxicity. This case highlights the importance of querying about non-prescription medications in evaluating the possibly harmful effects of various naturopathic products.