Li ZY, Li HL, Ji XW, et al. - Based on a population with very low prevalence of smoking and alcohol drinking, researchers explored the connections between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Using Cox regression models, the links between BMI at study registration and at age 20, waist circumference, hip circumference, waist-to-hip ratio, waist-to-height ratio, adult weight gain, and annual average weight gain with the risk of liver cancer were estimated. Two hundred forty-one liver cancer cases were identified from 69,296 candidates after a mean follow-up time of 17.5 years. Overall and abdominal obesity in middle age, as well as weight gain through adulthood, were positively linked to liver cancer risk among non-smoking and non-alcohol drinking women.