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Dorsal root ganglion stimulation normalizes measures of pain processing in patients with chronic low‐back pain: a prospective pilot study using quantitative sensory testing

Pain Practice Feb 04, 2021

Chapman KB, van Roosendaal BK, Yousef TA, et al. - In treatment of chronic low‐back pain (CLBP), dorsal root ganglion stimulation (DRG‐S) is used. CLBP patients are identified to exhibit lowered mechanoreceptive perception, decreased endogenous analgesia, as well as deep‐tissue hyperalgesia when compared with healthy controls. Researchers used quantitative sensory testing (QST) to determine if DRG‐S in CLBP patients results in modifications in pain processing. Patients underwent quantitative sensory testing before trial implantation of a DRG‐S system for CLBP and just before the trial lead removal or at 1‐month follow‐up after the permanent implant. Enrollment of 11 patients was performed (60 ± 16 years). Overall findings indicate that DRG‐S in CLBP patients lowers deep‐tissue hyperalgesia in the low back, while improving mechanoreceptive perception. Clinical improvements in pain and function were observed in accompaniment of these alterations in both neuropathic and nociceptive components of CLBP.

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