Donor age is the most important predictor of long term graft function in donation after cardiac death simultaneous pancreas-kidney transplantation: A retrospective study
American Journal of Surgery Mar 09, 2019
Chen J, et al. - As allografts donated after cardiac death (DCD) are the fastest growing organ source worldwide, researchers examined how donor characteristics, including age and BMI, influence outcomes of DCD simultaneous-pancreas-kidney transplantation (SPK) via evaluating UNOS DCD-SPK transplants from 1988-2012. They observed lower 1-year (73.4%±7.2% vs 88.2%±2.4%) and 10-year (50.3%±10% vs 66.3%±6.9%) pancreas survival, and twice the rate of kidney failure and pancreas failure with grafts>40(n=189) when compared to grafts≤40 (n=38). Pancreas failure and recipient mortality were also noted to be correlated with BMI. The predictive value of graft age for the outcome seems to be as good as the predictive value of pancreas and kidney donor risk indices.
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