da Silva PSL, et al. - In this study including 11 patients with severe head trauma (Glasgow Coma Scale score 4–8), researchers determined how intracranial pressure during tracheal suctioning is influenced by tracheal lidocaine administration. Prior to a standardized tracheal suctioning maneuver, they endotracheally instilled lidocaine (1.5 mg/kg) or saline solution. Using a crossover design, each patient was given both treatments. At four time points, ie, in baseline (T0), within 2 minutes (T1), 5 minutes (T2), and 15 minutes after tracheal instillation (T3), they evaluated cerebral hemodynamic and systemic and ventilatory impacts. Each treatment efficacy was determined by using 2-minute time interval around tracheal suctioning. In this preliminary study, an increase in intracranial pressure induced by tracheal suctioning could be reduced by tracheal lidocaine instillation. In addition, a faster return to the intracranial pressure baseline levels was favored by tracheal lidocaine instillation, without significant hemodynamic and ventilatory alterations.