Gavrilov SG, et al. - Via examining 30 women with varicose veins of the lower extremity only (VVLE) and another 45 women with VVLE and concomitant varicose veins of the pelvis (VVP) causing symptoms of the pelvic congestion syndrome (PCS), researchers investigated how PCS influences the clinical manifestations of chronic venous disease (CVD) of the lower extremities. CVD of class C2 (n = 47) or C3 (n = 28) according to the CEAP classification, was evident in all patients. Significantly more severe clinical manifestations of CVD, 4 times higher risk of leg pain, 7 times higher risk of leg edema, 5 times higher risk of leg heaviness, and in general 2 times more severe varicose veins were observed among patients with concomitant PCS, VVP and VVLE vs those with isolated VVLE without the signs of PCS and pelvic veins lesions. Findings thereby suggest the association of PCS with an increase in the incidence and severity of the CVD symptoms.