Schmeiser B, et al. - The effect of postoperative antiepileptic drug load on seizure control was evaluated in patients who underwent surgical treatment for pharmacoresistant mesiotemporal lobe epilepsy during the first 2 postoperative years. As per the outcomes, neither did a postoperative reduction in drug load significantly increase the risk for seizure relapse nor did increases in drug dosages cause an improvement in the seizure control. The effect of the surgical intervention was found to be the key determinant for seizure control rather than the postoperative drug regimen. A curative role of temporal lobe surgery was determined rather than an effect rendering the majority of patients’ pharmacoresponsive with a critical role of the antiepileptic drug regime for seizure control.