Chow S, et al. - Researchers investigated how chemotherapy and radiation influence the outcomes of surgical stage I uterine carcinosarcoma patients. From the National Cancer Database, they included data of 3,447 women with stage I uterine carcinosarcoma who underwent a hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection; median age at diagnosis: 66 years (range: 19–90 years). Among these women, 74.9% were white, 20.2% were black, and 2.4% were Asian. Overall, no adjuvant treatment was reported in 1,213 (35.2%) patients, whereas 698 (20.2%) received chemotherapy only (CT), 616 (17.9%) received radiation only (RT), and 920 (26.7%) received both CT and RT after surgery. Outcomes support adjuvant chemotherapy and radiation as beneficial for achieving better overall survival in stage I uterine carcinosarcoma. However, no benefit of adjuvant therapy was observed in the subset of those without myoinvasion.