Saponaro F, Pardi E, Mazoni L, et al. - Via performing this monocentric study, researchers sought to evaluate the clinical and biochemical profiles of patients with atypical parathyroid adenomas (APAs), retrospectively. In addition, they investigated the outcome after parathyroidectomy (PTX), and the presence of CDC73 germline and somatic mutations. Among 58 patients with a confirmed histopathological diagnosis of APA, 54 had sporadic PHPT and four had familial isolated hyperparathyroidism (FIHP). Comparison was made with age and gender-matched controls with parathyroid adenoma (PA). Significantly higher serum calcium and PTH levels were recorded in symptomatic vs asymptomatic patients. Relative to the sporadic counterpart, FIHP patients were younger (55±13 yrs vs 30±17yr). Significantly higher serum calcium and PTH levels and lower 25(OH)D concentration, BMD and T-score at 1/3 distal radius were reported among APA patients vs those with PA. Overall, a good prognosis was recorded for the large majority of patients with APA, despite a moderate/severe phenotype. Rate of persistent/recurrent disease was noted to be higher among germline CDC73 mutation-positive patients. Findings suggest no relevant role of CDC73 gene alterations in the tumorigenesis of sporadic APA.