Kahl U, Vens M, Pollok F, et al. - Given the reported correlation of diastolic dysfunction with the risk of postoperative major cardiovascular events, researchers here examined if higher doses of norepinephrine are required in patients with diastolic dysfunction during general anesthesia and investigated the correlation between the grade of diastolic dysfunction and the E/e’ ratio during anesthesia. A high E/e’ ratio corresponds to raised filling pressures and is a relevant measure of impaired diastolic function. This prospective observational cohort study was conducted at a German university hospital enrolling 247 patients aged ≥ 60 years and undergoing general anesthesia (ie, propofol and sevoflurane) for elective noncardiac surgery. Outcomes yielded no evidence supporting the correlation between diastolic dysfunction and impaired hemodynamic function, as expressed by high vasopressor support during anesthesia. In addition, findings suggest no worsening of diastolic function, as expressed by the E/e’ ratio, during anesthesia.