Brekke AC, et al. - Experts observed the impacts of peri-operative dexamethasone on the acute phase response (APR) following total knee arthroplasty (TKA) by trending CRP (C-reactive protein) (mg/L) and fibrinogen (mg/dL), presuming that the anti-inflammatory effects of dexamethasone can attenuate the APR after TKA and will be associated with decreased post-operative pain and nausea. The hypothesis that the APR following TKA can be attenuated pharmacologically by corticosteroids was supported in the findings. In patients receiving dexamethasone, postoperative morphine equivalents administered was significantly decreased, with no difference observed in anti-emetic use.