Legha A, Burke DL, Foster NE, et al. - Experts aspired to explore if comorbidities anticipate pain and function following an exercise intervention in people with knee OA and if they moderate response to: exercise vs no exercise; and enhanced exercise vs usual exercise-based care. Existing data were analyzed from three randomized controlled trials: TOPIK (n = 217), APEX (n = 352) and Benefits of Effective Exercise for knee Pain (n = 514). According to findings, obesity and anxiety/depression anticipated pain and function results in people offered an exercise intervention, but only the presence of cardiac problems could moderate the impact of knee OA exercise. There is a need for more confirmatory inquiries.