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Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?

Molecular Psychiatry Jun 26, 2019

Barker ED, et al. - Researchers sought to determine the genetic and phenotypic relationships between attention deficit hyperactivity disorder (ADHD) and body mass index (BMI) via assessing the relationships between polygenic risk score (PRS) scores and phenotypes for these traits. In addition, they investigated the associations between the PRS scores for ADHD and BMI, whole-brain structural variation, as well as a functional neuroimaging measure that assesses reward-related impulsivity. In line with previous ADHD-related research, outcomes support an association between these two phenotypes. Further, they noted the correlation of the PRS scores for ADHD and BMI with each other and with grey matter across the brain and contrast maps derived from fMRI scans conducted during the MID task. Importantly, an association of these neuroimaging measures with the phenotypes of impulsivity and BMI was also observed.

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