Vaughan DA, et al. - This study was intended to evaluate the correlation between sperm DNA fragmentation and oxidative stress (OS) with increasing male age. Researchers conducted a retrospective cohort study including a total of 16,945 semen samples analysed at a single reference laboratory between January 2010 and December 2018. The cohort was categorized into seven age categories: <30, 30–34, 35–39, 40–44, 45–49, 50 to < 54 and ≥ 55 years (the mean age was 37.6 years (SD 6.8). The flow cytometry was applied to estimate the sperm DNA fragmentation index and high DNA stainability (HDS). They evaluated OS levels applying the oxidative stress adducts test, by spectrophotometry.  In sperm, DNA and/or oxidative damage may be just as important to understand as the chromosomal aberrations that are carried in the oocyte. Future evaluations are required to investigate the impact of advancing paternal age on the male genome and, ultimately, on the health of the offspring.