Choi WT, et al. - Given that a small subset of serrated lesions (SLs) harbour TP53 mutations and Wnt/β-catenin pathway activation, suggesting their risk of developing dysplasia or colorectal cancer (CRC) via a ‘chromosomal instability (CIN)-like’ pathway, researchers investigated if aneuploidy (characteristic of conventional adenoma) ever develops in SLs and is associated with development of dysplasia or CRC, in this context. A small subset of ‘serrated epithelial change’ (SEC) and traditional serrated adenoma (TSA) cases displayed aneuploidy, unlike sessile serrated adenomas (SSAs) and hyperplastic polyps (HPs), suggesting that they can develop neoplasia via the CIN pathway. They suggest performing DNA content analysis of a larger number of SEC cases, with adequate follow-up, for a more precise determination of aneuploidy incidence and neoplasia risk.