Radzikowska U, Ding M, Tan G, et al. - In order to ascertain the range of human cells and tissues targeted by SARS‐CoV‐2, its potential receptors and associated regulating factors, researchers here examined the expression of known and potential SARS‐CoV‐2 receptors and linked molecules in the extensive collection of primary human cells and tissues from healthy individuals of different age and from cases with risk factors and known comorbidities of COVID‐19. Per data gained, there is potential involvement of different receptor repertoire in the SARS‐CoV‐2 infection at the epithelial barriers and in the immune cells. The epithelial sites of the lung and skin showed coexpression of ACE2 and TMPRSS2, whereas in both epithelium and in immune cell, expression of CD147 (BSG), cyclophilins (PPIA and PPIB), CD26 (DPP4), and related molecules was identified. In addition, a distinct age‐related expression profile of these genes was observed in the PBMCs and T cells from healthy children and adults. They noted higher expression of ACE2‐ and CD147‐related genes in the bronchial biopsy, BAL, or blood generally in correlation with presence of asthma, COPD, hypertension, smoking, obesity, and male gender status. Additionally, they noted positive correlation of CD147‐related genes with age and BMI. Interestingly, expression of CD147‐related genes was noted to be higher in the lesional skin of patients with atopic dermatitis.