Terada Y, Kaburaki T, Takase H, et al. - Researchers conducted this retrospective, multicenter, case series to determine distinguishing features of the clinical characteristics of anterior uveitis (AU) caused by herpes simplex virus (HSV), varicella-zoster virus (VZV) and cytomegalovirus (CMV). Between January 2012 and December 2017, consecutive patients with herpetic AU examined at 11 tertiary centers in Japan and who were followed for 3 months or longer were assessed. This investigation recruited 259 herpetic AU patients, including PCR-proven HSV-AU (30 patients), VZV-AU (50) and CMV-AU (147); and herpes zoster ophthalmicus (32). Ocular hyperemia and pain, blurred vision, ciliary injection, medium to large keratic precipitates (KPs), cells and flare in the anterior chamber, and posterior synechia were significantly more common in HSV-AU and VZV-AU compared with CMV-AU. Small KPs, coin-shaped KPs, diffuse iris atrophy, elevated intraocular pressure and glaucoma surgery, on the other hand, were significantly more common in CMV-AU vs HSV-AU and VZV-AU.