Torchen LC, et al. - Because female relatives of women with PCOS, including postmenopausal mothers and premenarchal daughters (PCOS-d), have elevated testosterone (T) levels consistent with a genetic susceptibility to this phenotype, researchers tested the premise that premenarchal PCOS-d have distinctive phenotypic features compared to obese girls (OB-g). For this investigation, they studied 48 PCOS-d, 30 OB-g and 22 normal weight (NW-g) premenarchal girls. According to findings, PCOS-d had increased AMH levels compared to OB-g, in spite of similarly elevated free T levels. This finding suggests that ovarian folliculogenesis, a key reproductive feature of PCOS, is lacking in OB-g alterations. Causal mechanisms in PCOS-d or OB-g may differ, or an early marker for PCOS may not be elevated T in OB-g.