Buscot MJ, et al. - Researchers wanted to define trajectories from early childhood to adulthood (6–49 years) based on body mass index (BMI) and their relationship with CVD risk factors [type 2 diabetes mellitus (T2DM), high-risk lipid levels, hypertension, and high carotid intima-media thickness (cIMT)] in adulthood (34–49 years)]. Six discrete long-term BMI trajectories were recognized using participants from the Cardiovascular Risk in Young Finns Study. Trajectories that included BMIs that reached or persisted at high levels were found to be related to CVD risk factors in adulthood. To limit and reduce adverse cardiometabolic profiles, stabilizing BMI in obese adults and resolving elevated child BMI by adulthood might help. The most effective strategy to reduce the risk for adult atherosclerosis might be preventing child obesity.