Mimouni M, et al. – A retrospective cohort study is carried out to figure out if spectral domain–optical coherence tomography (SD–OCT) disorganization of the retinal inner layers (DRIL) is predictive of best–corrected visual acuity (BCVA) in retinal vein occlusion macular edema (RVO–ME). The change of the DRIL extent following the first three monthly injections identifies eyes with a high likelihood of subsequent BCVA improvement or decline. Therefore, the extent of DRIL before and after treatment is an additional SD–OCT parameter that may serve as a biomarker for patients with RVO–ME.