Kurita N, Kamitani T, Wada O, et al. - This study was undertaken to investigate the relationship between serum muscle biomarkers and sarcopenia among patients with osteoarthritis (OA), considering the presence of pain and inflammation. Researchers enrolled a total of 1,425 patients with knee and hip OA scheduled for joint replacement surgery in a single-center cross-sectional study from Screening for People Suffering Sarcopenia in Orthopedic cohort of Kobe study. They evaluated pain and inflammation using the numeric rating scale and serum C-reactive protein levels, respectively. Logistic regression models were applied to evaluate the relationships between the biomarkers (serum creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase) and sarcopenia. There is a correlation between serum creatine phosphokinase and sarcopenia, implying the potential utility for sarcopenia detection regardless of pain or inflammation in OA.