Capuano V, Sacconi R, Borrelli E, et al. - Researchers conducted this retrospective, longitudinal, case series study to describe the “dimple,” a previously unreported structural optical coherence tomography (OCT) finding in vascularized serous pigment epithelial detachment (PED) secondary to neovascular age-related macular degeneration (AMD). Participants in the study were 18 patients (19 eyes). Two dimple phenotypes were described in the OCT analysis: type 1 or (“top denting”) (9 eyes) and type 2 (or “side denting”) (10 eyes). Findings suggested an association of both phenotypes with hyper-reflective holding sub-retinal pigment epithelium (RPE) band encompassing the posterior face of the RPE and extending to the Bruch’s membrane. In all cases, hyper-reflective holding band is not associated with angiographic signs of neovascular tissue. No case of RPE tear was observed during follow-up. The characteristics of the dimple and its association with hyper-reflective holding sub-RPE bands in the context of large vascularized serous PED in neovascular AMD were described in this analysis. The presence of a dimple does not appear to be an additional risk factor for developing RPE tearing secondary to neovascular AMD in high-risk PED.