• Profile
Close

Differentially expressed microRNAs as diagnostic biomarkers for infected tibial non-union

Injury Sep 19, 2020

Dai Y, Huang L, Zhang H, et al. - In this study, for the first time, novel diagnostic microRNAs (miRNAs) biomarkers and therapeutic targets were investigated in infected tibial non-union. Microarray analysis revealed 20 differentially expressed miRNAs in cases with infected tibial non-union and closed tibial fractures. Researchers further confirmed the differential expression of miR-649, miR-29b-3p, miR-498, miR-365a-5p, miR-328-5p, and miR-345-3p in a validation cohort. An overall diagnostic accuracy of AUC = 0.953 was attained using combination of three miRNAs (miR-649, miR-328-5p, and miR-345-3p). The findings indicate the role of miR-649, miR-328-5p, and miR-345-3p as novel candidate biomarkers for infected tibial non-union diagnosis, suggesting the utility of these deferentially expressed miRNAs as novel diagnostic and therapeutic tools to identify infected tibial non-union.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay