Bryant RA, Erlinger M, Felmingham K, et al. - The present study was sought to evaluate neural markers of treatment response, specifically the prediction of remission of specific posttraumatic stress disorder (PTSD) symptoms. Researchers evaluated PTSD treatment‐seeking patients (n  = 40) before trauma‐focused cognitive behavioral therapy (TF‐CBT) during functional magnetic brain resonance imaging (fMRI) when they processed fearful, sad, happy, and neutral faces. Individuals had undergone nine sessions of TF‐CBT and were independently evaluated on the Clinician‐Administered PTSD Scale (CAPS) following treatment. They compared treatment responders and nonresponders with healthy controls (n  = 40). With the CAPS, the severity of PTSD was analyzed. fMRI responses were estimated for each emotion face correlated with neutral contrast, which were matched with a reduction in PTSD severity from pretreatment to posttreatment. Via at least 50% reduction in the severity of PTSD, treatment response was classified. This study's findings demonstrate that positive response to TF‐CBT is prognosticated during emotion processing by normal levels of recruitment of neural networks implicated in emotional information. These data imply that distinct neural networks are predictive of PTSD fear and dysphoric symptom reduction following TF‐CBT.