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Differential mortality and the excess rates of hip fracture associated with type 2 diabetes: Accounting for competing risks in fracture prediction matters

Journal of Bone and Mineral Research May 23, 2018

Tebé C, et al. - Researchers ascertained the effect of mortality as a competing risk in the study of the relationship between Type 2 diabetes (T2DM) and hip fracture rates in this population-based cohort study. Compared to matched non-T2DM, a 50% increased mortality and, after adjusting for differential survival at 5 years, a 21% increased incidence of hip fracture was seen in T2DM patients. An overestimation of fracture risk was led by failing to account for differential mortality. The association between T2DM and hip fracture risk remained statistically significant accounting for death as a competing event, and the probability of a hip fracture within 5 years was 2.3% for TD2M and 1.9% for non-TD2M patients vs 2.6% and 2.1% respectively using Kaplan-Meier (KM) estimates.
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