Takousis P, Sadlon A, Schulz J, et al. - Since several microRNAs (miRNAs) were involved in the pathogenesis of Alzheimer disease, however, evidence from individual case-control studies remains inconclusive, researchers analyzed differential expression of miRNAs in Alzheimer disease brain, blood, and cerebrospinal fluid. In 461 meta-analyses, data from 147 independent data sets were quantitatively evaluated across 107 publications. According to findings, 25, five, and 32 miRNAs showed significant differential expression across the study (α < 1·08 × 10⁻⁴) in brain, cerebrospinal fluid, and blood-derived specimens, respectively, with 5 miRNAs showing differential expression in both brain and blood. In the abstracts of previous original or review articles, 13 of those 57 miRNAs were not reported. The systematic evaluation of differential miRNA expression in Alzheimer disease is the first of its kind and highlights the potential significance of several miRNAs.