Lee J, Kim H, Kim J, et al. - Researchers used clinical and neuroimaging characteristics to examine predictive factors for the upper extremity (UE) and lower extremity (LE) motor recovery after stroke. Forty‐two patients with subacute ischemic stroke underwent structural and functional MRI data acquisition and cognitive/behavioral evaluation using the Fugl‐Meyer assessment, NIH Stroke Scale (NIHSS), and Mini‐Mental State Examination (MMSE) two weeks after the onset of the stroke. For UE and LE, early clinical and neuroimaging factors were significantly different for predicting motor recovery. Age, NIHSS, MMSE, CST lesion load, lesion volume, ipsilesional CST integrity, and IHFC were all related to UE motor function recovery. On the other hand, LE motor recovery was linked to ipsilesional and contralesional CST integrity, and MMSE. Specifically, LE recovery demonstrated a clear link to cognitive function preservation relative to motor impairment. The findings showed that different mechanisms underlie UE and LE motor recovery after stroke. Cognitive functions appeared to modulate LE motor recovery more intensively than UE.