Chen L, et al. - The different clinical features between pediatric-onset and adult-onset immunoglobulin against myelin oligodendrocyte glycoprotein (MOG-IgG)-seropositive patients were compared in a relatively large cohort of 816 consecutive patients. Observations demonstrate distinctive features between pediatric-onset and adult-onset patients with MOG-IgG. The two groups demonstrated significant differences in time to first relapse (pediatric-onset group, 8(3-12) months; adult-onset group, 11(3–51) months) and cerebral symptoms [significantly higher in pediatric-onset patients than in adult-onset patients, either at disease onset or throughout the course of disease]. Optic nerve symptoms were more common in adult-onset groups, but no significant difference was found between the two groups. In only adult-onset patients, the MOG-IgG titer demonstrated a significant positive correlation with total protein levels in cerebrospinal fluid. They observed extensive white matter lesions on magnetic resonance imaging in both groups, and the number was much higher in pediatric-onset (7/15, 46.7%) than in adult-onset patients (4/29, 13.8%). Compared to the adult-onset patients, more pediatric-onset patients experienced complete recovery at the last follow-up.