de Luis DA, et al. - In this investigation involving 270 obese people, researchers assessed the impact of rs16147 on body weight and biochemical changes following a high-protein/low-carbohydrate hypocaloric diet vs a standard severe hypocaloric diet over 9 months. Participants were allocated randomly for a 9-month period to one of two hypocaloric diets, high protein (Diet HP) or standard (Diet S). According to findings, all genotypes exhibited reduced BMI, weight, fat mass, waist circumference, and leptin levels after both diets. Candidates with the minor allele (A) assigned to the HP diet exhibited reductions in total cholesterol, LDL cholesterol, triglycerides, insulin, HOMA–IR, and CRP. In addition, candidates with the minor allele assigned to diet S displayed reductions in total cholesterol, LDL-cholesterol, triglycerides, insulin, HOMA–IR, and CRP. The authors concluded that the presence of the A allele of the rs16147 genetic variant in obese Caucasians produces a better metabolic response which is secondary to weight loss with two different hypocaloric diets.