Mørk FCB, Madsen JOB, Jensen AK, et al. - According to this longitudinal cohort study, a percentage of children and adolescents exhibit impaired insulin sensitivity (IS) throughout the remission phase of paediatric type 1 diabetes (T1D) and are still not in remission 14.5 months following diagnosis, despite stimulated c-peptide > 300 pmol/L.

• Seventy-eight children and adolescents ranging in age from 3.3 to 17.7 years were enrolled in the study.

• At 14.5 months after diagnosis, 54.5% of the candidates with stimulated c-peptide > 300 pmol/L were not in partial remission.

• Patients who were not in remission had significantly lower IS 2.5 and 14.5 months after diagnosis as compared with participants who were in partial remission and had equivalent c-peptide levels.

• During the remission phase, IS did not fluctuate.