Stolz D, et al. - In this retrospective cohort study utilizing electronic medical records data, researchers evaluated variations in COPD expression, in a systematic manner, between women and men in UK primary care clinics who were newly diagnosed with COPD. Incident patients were 22,429; 48% of COPD patients were women. Findings revealed 17% greater risk of first moderate or severe exacerbation in women vs in men, with a median time to first exacerbation of 504 days and 637 days for women and for men, respectively. In the younger age group (≥ 40 years to < 65 years), in Global Initiative for Chronic Obstructive Lung Disease 2016 groups B, C, and D and in subjects with moderate to severe airflow obstruction, these differences were more prominent. The first, second, and third year of follow-up revealed a higher annual rate of moderate or severe exacerbations in women vs men. According to the findings, the need for appropriate detection and treatment of women with COPD in clinical practice remained unmet.