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Differences in clinical characteristics and outcomes between men and women with idiopathic pulmonary fibrosis: A multicenter retrospective cohort study

Chest Feb 28, 2020

Zaman T, et al. - Researchers pooled two tertiary care center idiopathic pulmonary fibrosis (IPF) cohorts to determine if there exist any disparities in clinical disease features and outcomes between men and women with IPF. They examined gender discrepancies in outcomes of time to lung transplantation or death. Overall 1,263 patients were analyzed, about 71% of whom were men. They analyzed predictors of outcome including age, forced vital capacity percent predicted, diffusion capacity for carbon monoxide percent predicted (DLCO%), body mass index, smoking history, and respiratory variables of cough, phlegm, and demand for supplemental oxygen. A negative link with transplant-free survival was shown by older age, lower DLCO%, and presence of cough or phlegm, in men but not in women, however, only the link for cough varied statistically by gender. In IPF, worse transplant-free survival was reported in relation to the male gender. In this population, cough was suggested as the likely gender-specific predictor of survival.
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