Differences in clinical characteristics and outcomes between men and women with idiopathic pulmonary fibrosis
Chest Apr 17, 2020
Zaman T, et al. - Researchers compared men and women with idiopathic pulmonary fibrosis (IPF) in terms of clinical disease features and outcomes. They pooled 2 tertiary care center IPF cohorts to examine gender disparities in outcomes of time to lung transplantation or mortality. The pooled cohort with follow-up data involved 1,263 patients, about 71% were men. In men but not in women, older age, lower diffusion capacity for carbon monoxide % predicted, as well as the presence of cough or phlegm were found to be negatively related to transplant-free survival, but only the link for cough varied statistically by gender. Overall, findings revealed a link between male gender and worse transplant-free survival in IPF. In this patient population, cough may represent a gender-specific predictor of survival.
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