Saeki H, Baba N, Ito K, et al. - Researchers conducted this phase 3 randomized, double-blind, vehicle-controlled trial with the aim to establish the superiority of topical difamilast to vehicle in Japanese pediatric patients with atopic dermatitis (AD). Participants were patients aged 2–14 years with an Investigator Global Assessment (IGA) score of 2 or 3. They were administered difamilast 0·3% (n = 83), difamilast 1% (n = 85) or vehicle (n = 83) ointment twice daily for 4 weeks. Outcomes support the superiority of difamilast 0·3% and 1% ointments to vehicle in Japanese pediatric patients with AD and the patients showed good tolerability towards this treatment.