Bowen KJ, et al. - In a multi-center, double-blind, randomized, 3-period crossover, controlled feeding trial, researchers assessed how lipids, lipoproteins, and apolipoproteins (apos) were influenced by diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) in 44 men and 75 women, with a mean age of 44 years, mean body mass index (BMI; in kg/m2) of 31.7, and an increased waist circumference plus ≥1 metabolic syndrome criteria. For 6 weeks with ≥4-week washouts, these subjects were asked to consume prepared, weight-maintenance diets containing canola oil (17.5% monounsaturated fatty acids [MUFAs], 9.2% polyunsaturated fatty acids [PUFAs], 6.6% saturated fatty acids [SFAs]), HOCO (19.1% MUFAs, 7.0% PUFAs, 6.4% SFAs), or control oil (10.5% MUFAs, 10.0% PUFAs, 12.3% SFAs). Lower endpoint total cholesterol, LDL cholesterol, apoB, and non-HDL cholesterol was seen with canola and HOCO diets vs the control; no differences were seen between canola diets. After the HOCO diet vs the control diet, TC:HDL cholesterol and apoB:apoA1 ratios were lower. Triglyceride, HDL cholesterol, or apoA1 concentrations were not impacted by diet.