Jiang H, et al. - In this meta-analysis of 8 randomized controlled trials (RCTs) and 12 cohort studies, researchers assessed the association of dietary vitamin and carotenoid intake with age-related cataract (ARC) risk. These studies were identified from MEDLINE, EMBASE, ISI Web of Science, and Cochrane Library databases from inception to June 2018. In the cohort studies, a significant association of most vitamins and carotenoids with reduced risk of ARC was reported, including vitamin A, vitamin C, vitamin E, β-carotene, and lutein or zeaxanthin. No significant reduction in the risk of ARC was observed with vitamin E or β-carotene intervention vs the placebo group in RCTs. For every 10-mg/d increase in lutein or zeaxanthin intake, a significant decrease in ARC risk by 26% was observed in cohort studies, with reduction by 18% for each 500-mg/d increase in vitamin C intake, by 8% for each 5-mg/d increase in β-carotene intake, and by 6% for every 5 mg/d increase in vitamin A intake. A significant decreased risk of ARC was reported in relation to higher consumption of certain vitamins and carotenoids in cohort studies, but evidence obtained from RCTs was not as clear.