Zhu Y, et al. - Researchers, for the first time, examined the impact of dietary total fat and fatty acid intake on cardiovascular diseases (CVDs) risk based on dose-response meta-analysis of prospective cohort studies. Cohort studies assessing associations of dietary fat intake and CVD risk were searcher for until July 1, 2018 in Pubmed, Embase and Cochrane Library. Findings suggested there was no association of total fat, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids (PUFA) intake with the risk of cardiovascular disease. In a dose-response fashion, researchers found higher trans fatty acids (TFA) intake was related to higher risk of CVDs, and the subgroup analysis found PUFA had a cardioprotective effect in more than 10 years of follow-up studies. Dose-response analysis proposed that the risk of CVDs was 16% higher for an increment of 2% energy/day of TFA intake.