Krok-Schoen JL, et al. - Researchers used a prospective cohort study design to assess the associations of long-chain n-3 polyunsaturated fatty acids intake with osteoarthritis (OA) and rheumatoid arthritis (RA) risk among 80,551 postmenopausal women, aged 55 to 79 years with no history of arthritis, recruited into the Women’s Health Initiative Observational Study and Clinical Trials cohort between 1993 and 1998, having completed a 120-item food frequency questionnaire at baseline. These women were followed-up for 8 years and the findings yielded no evidence of benefit of long-chain n-3 polyunsaturated fatty acids intake in relation to arthritis risk, though these nutrients have therapeutic potential. This inquiry is the first to assess associations of long-chain n-3 polyunsaturated fatty acids with OA risk and the largest to examine associations with RA risk.