Aglago EK, Murphy N, Huybrechts I, et al. - This study was undertaken to explore the relationship between dietary estimates and plasma levels of individual and total saturated, monounsaturated, industrial‐processed trans, and ruminant‐sourced trans fatty acids, and colorectal cancer (CRC) risk in the European Prospective Investigation into Cancer and Nutrition. Researchers calculated baseline fatty acid intakes in 450,112 participants (6,162 developed CRC, median follow‐up = 15 years). Plasma phospholipid fatty acids were ascertained by gas chromatography in 433 colon cancer cases and 433 matched controls in a nested case‐control study. Cox and conditional logistic regression were used to calculate multivariable‐adjusted hazard ratios and odds ratios with 95% confidence intervals. The outcomes imply that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the etiology of CRC. It was shown that both dietary and plasma myristic acid levels were inversely correlated with colon cancer risk, which needs future study.